On-chip spatiotemporal electrophysiological analysis of human stem cell derived cardiomyocytes enables quantitative assessment of proarrhythmia in drug development

We examined a simultaneous combined spatiotemporal field potential duration (FPD) and cell-to-cell conduction time (CT) in lined-up shaped human embryonic stem cell-derived cardiomyocytes (hESC-CMs) using an on-chip multielectrode array (MEA) system to evaluate two origins of lethal arrhythmia, repo...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Asahi, Yumiko, Hamada, Tomoyo, Hattori, Akihiro, Matsuura, Kenji, Odaka, Masao, Nomura, Fumimasa, Kaneko, Tomoyuki, Abe, Yasuyuki, Takasuna, Kiyoshi, Sanbuissho, Atsushi, Yasuda, Kenji
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6162288/
https://ncbi.nlm.nih.gov/pubmed/30266924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-32921-1
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