High-affinity IgM(+) memory B cells are defective in differentiation into IgM antibody-secreting cells by re-stimulation with a T cell-dependent antigen

IgM antibodies (Abs) are thought to play a major role in humoral immunity but only at the early stage of the primary immune response. However, two subsets of IgM(+) memory B cells (MBCs), one with high affinity gained by means of multiple somatic hypermutation (SHM) and the other with low affinity a...

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Vydáno v:Sci Rep
Hlavní autoři: Tashiro, Yasuyuki, Murakami, Akikazu, Hara, Yasushi, Shimizu, Takeyuki, Kubo, Masato, Goitsuka, Ryo, Kishimoto, Hidehiro, Azuma, Takachika
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6162211/
https://ncbi.nlm.nih.gov/pubmed/30266961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-32926-w
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