Effects of PEG surface density and chain length on the pharmacokinetics and biodistribution of methotrexate-loaded chitosan nanoparticles

BACKGROUND: One of the most important aspects of drug delivery is extended nanoparticle (NP) residence time in vivo. Herein, we report a series of methotrexate (MTX)-loaded chito-san (CS) NPs coated with differently sized methoxy polyethylene glycol (mPEG) at different mPEG surface densities. MATERI...

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Enregistré dans:
Détails bibliographiques
Publié dans:Int J Nanomedicine
Auteurs principaux: Ait Bachir, Zaina, Huang, YuKun, He, MuYe, Huang, Lei, Hou, XinYu, Chen, RongJun, Gao, Feng
Format: Artigo
Langue:Inglês
Publié: Dove Medical Press 2018
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6161721/
https://ncbi.nlm.nih.gov/pubmed/30288039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S167443
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