APOE ε4 is associated with severity of Lewy body pathology independent of Alzheimer pathology

OBJECTIVE: To evaluate whether APOE ε4 is associated with severity of Lewy body (LB) pathology, independently of Alzheimer disease (AD) pathology. METHODS: Six hundred fifty-two autopsy-confirmed LB disease (LBD) cases and 660 clinical controls were genotyped for APOE. In case-control analysis, LBD...

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Detalhes bibliográficos
Publicado no:Neurology
Main Authors: Dickson, Dennis W., Heckman, Michael G., Murray, Melissa E., Soto, Alexandra I., Walton, Ronald L., Diehl, Nancy N., van Gerpen, Jay A., Uitti, Ryan J., Wszolek, Zbigniew K., Ertekin-Taner, Nilüfer, Knopman, David S., Petersen, Ronald C., Graff-Radford, Neill R., Boeve, Bradley F., Bu, Guojun, Ferman, Tanis J., Ross, Owen A.
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6161556/
https://ncbi.nlm.nih.gov/pubmed/30143564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000006212
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