Exploring the Metabolism of Loxoprofen in Liver Microsomes: The Role of Cytochrome P450 and UDP-Glucuronosyltransferase in Its Biotransformation

Loxoprofen, a propionic acid derivative, non-steroidal anti-inflammatory drug (NSAID) is a prodrug that is reduced to its active metabolite, trans-alcohol form (Trans-OH) by carbonyl reductase enzyme in the liver. Previous studies demonstrated the hydroxylation and glucuronidation of loxoprofen. How...

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Bibliographic Details
Published in:Pharmaceutics
Main Authors: Shrestha, Riya, Cho, Pil Joung, Paudel, Sanjita, Shrestha, Aarajana, Kang, Mi Jeong, Jeong, Tae Cheon, Lee, Eung-Seok, Lee, Sangkyu
Format: Artigo
Language:Inglês
Published: MDPI 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6160907/
https://ncbi.nlm.nih.gov/pubmed/30072626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics10030112
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