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High expression of sonic hedgehog in allergic airway epithelia contributes to goblet cell metaplasia

Sonic hedgehog (SHH) is abundantly expressed and critical for morphogenesis in embryonic lungs, however, SHH expression drops to a much lower level in mice from E17.5 and in humans from the 21st gestational week. We find that SHH expression is robustly up-regulated in the airway epithelia of childre...

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Detalhes bibliográficos
Publicado no:Mucosal Immunol
Main Authors: Xu, Chengyun, Zou, Chaochun, Hussain, Musaddique, Shi, Wei, Shao, Yanan, Jiang, Ziyan, Wu, Xiling, Lu, Meiping, Wu, Junsong, Xie, Qiangmin, Ke, Yuehai, Long, Fanxin, Tang, Lanfang, Wu, Ximei
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6160330/
https://ncbi.nlm.nih.gov/pubmed/29867080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41385-018-0033-4
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