Cilostazol disrupts TLR-4, Akt/GSK-3β/CREB, and IL-6/JAK-2/STAT-3/SOCS-3 crosstalk in a rat model of Huntington's disease

Countless neurodegenerative diseases are associated with perverse multiple targets of cyclic nucleotide signalling, hastening neuronal death. Cilostazol, a phosphodiesterase-III inhibitor, exerts neuroprotective effects against sundry models of neurotoxicity, however, its role against Huntington’s d...

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Udgivet i:PLoS One
Main Authors: El-Abhar, Hanan, Abd El Fattah, Mai A., Wadie, Walaa, El-Tanbouly, Dalia M.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6160003/
https://ncbi.nlm.nih.gov/pubmed/30260985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0203837
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