PD-1 blockade partially recovers dysfunctional virus–specific B cells in chronic hepatitis B infection

Chronic HBV (CHB) infection suppresses virus-specific T cells, but its impact on humoral immunity has been poorly analyzed. Here, we developed a dual-staining method that utilizes hepatitis B virus (HBV) surface antigens (HBsAg) labeled with fluorochromes as “baits” for specific ex vivo detection of...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Salimzadeh, Loghman, Le Bert, Nina, Dutertre, Charles-A., Gill, Upkar S., Newell, Evan W., Frey, Christian, Hung, Magdeleine, Novikov, Nikolai, Fletcher, Simon, Kennedy, Patrick T.F., Bertoletti, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6159957/
https://ncbi.nlm.nih.gov/pubmed/30084841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI121957
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