Circadian rhythm disruption impairs tissue homeostasis and exacerbates chronic inflammation in the intestine

Endogenous circadian clocks regulate 24-h rhythms of physiology and behavior. Circadian rhythm disruption (CRD) is suggested as a risk factor for inflammatory bowel disease. However, the underlying molecular mechanisms remain unknown. Intestinal biopsies from Per1/2 mutant and wild-type (WT) mice we...

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Veröffentlicht in:FASEB J
Hauptverfasser: Pagel, René, Bär, Florian, Schröder, Torsten, Sünderhauf, Annika, Künstner, Axel, Ibrahim, Saleh M., Autenrieth, Stella E., Kalies, Kathrin, König, Peter, Tsang, Anthony H., Bettenworth, Dominik, Divanovic, Senad, Lehnert, Hendrik, Fellermann, Klaus, Oster, Henrik, Derer, Stefanie, Sina, Christian
Format: Artigo
Sprache:Inglês
Veröffentlicht: Federation of American Societies for Experimental Biology 2017
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6159707/
https://ncbi.nlm.nih.gov/pubmed/28710114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201700141RR
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