The structure of human Nocturnin reveals a conserved ribonuclease domain that represses target transcript translation and abundance in cells

The circadian protein Nocturnin (NOCT) belongs to the exonuclease, endonuclease and phosphatase superfamily and is most similar to the CCR4-class of deadenylases that degrade the poly-adenosine tails of mRNAs. NOCT-deficient mice are resistant to high-fat diet induced weight gain, and exhibit dysreg...

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Udgivet i:Nucleic Acids Res
Main Authors: Abshire, Elizabeth T, Chasseur, Jennifer, Bohn, Jennifer A, Del Rizzo, Paul A, Freddolino, Peter L, Goldstrohm, Aaron C, Trievel, Raymond C
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2018
Fag:
Nucleic Acid Enzymes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6158716/
https://ncbi.nlm.nih.gov/pubmed/29860338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky412
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