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Investigating the mechanistic basis of biomechanical input controlling skeletal development: exploring the interplay with Wnt signalling at the joint

Embryo movement is essential to the formation of a functional skeleton. Using mouse and chick models, we previously showed that mechanical forces influence gene regulation and tissue patterning, particularly at developing limb joints. However, the molecular mechanisms that underpin the influence of...

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Detalhes bibliográficos
Publicado no:Philos Trans R Soc Lond B Biol Sci
Main Authors: Rolfe, Rebecca A., Shea, Claire A., Singh, Pratik Narendra Pratap, Bandyopadhyay, Amitabha, Murphy, Paula
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6158205/
https://ncbi.nlm.nih.gov/pubmed/30249778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2017.0329
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