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The phosphodiesterase 9 inhibitor PF-04449613 promotes dendritic spine formation and performance improvement after motor learning
The cyclic nucleotide cGMP is an intracellular second messenger with important roles in neuronal functions and animals’ behaviors. The phosphodiesterases (PDEs) are a family of enzymes that hydrolyze the second messengers cGMP and cAMP. Inhibition of phosphodiesterase 9 (PDE9), a main isoform of PDE...
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| Publicado no: | Dev Neurobiol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6158093/ https://ncbi.nlm.nih.gov/pubmed/30022611 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dneu.22623 |
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