Transcriptional Repressor Kaiso Promotes Epithelial to Mesenchymal Transition and Metastasis in Prostate Cancer through Direct Regulation of miR-200c

The loss of miR-200 family, through DNA methylation, results in cancer cells undergoing an epithelial to mesenchymal transition (EMT), and metastasis. In this study, we established that the transcriptional repressor Kaiso directly binds methylated regions of the miR-200 family, and this is reversed...

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Detalhes bibliográficos
Publicado no:Cancer Lett
Main Authors: Abisoye-Ogunniyan, Abisola, Lin, Huxian, Ghebremedhin, Anghesom, Salam, Ahmad, Karanam, Balasubramanyam, Theodore, Shaniece, Jones-Trich, Jacqueline, Davis, Melissa, Grizzle, William, Wang, Honghe, Yates, Clayton
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6158022/
https://ncbi.nlm.nih.gov/pubmed/29751044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2018.04.044
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