Evaluating biological activity of compounds by transcription factor activity profiling

Assessing the biological activity of compounds is an essential objective of biomedical research. We show that one can infer the bioactivity of compounds by assessing the activity of transcription factors (TFs) that regulate gene expression. Using a multiplex reporter system, the FACTORIAL, we charac...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Medvedev, Alexander, Moeser, Matt, Medvedeva, Liubov, Martsen, Elena, Granick, Alexander, Raines, Lydia, Zeng, Ming, Makarov, Sergei, Houck, Keith A., Makarov, Sergei S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6157966/
https://ncbi.nlm.nih.gov/pubmed/30263952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aar4666
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