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Automated Scale Reduction of Nonlinear QSP Models With an Illustrative Application to a Bone Biology System
Integrating quantitative systems pharmacology (QSP) into pharmacokinetics/pharmacodynamics (PKPD) has resulted in models that are highly complex and often not amenable to further exploration via estimation or design. Because QSP models are usually depicted using nonlinear differential equations it i...
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| Publicado no: | CPT Pharmacometrics Syst Pharmacol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6157701/ https://ncbi.nlm.nih.gov/pubmed/30043496 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12324 |
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