Autoreactive IgG and IgA B Cells Evolve through Distinct Subclass Switch Pathways in the Autoimmune Disease Pemphigus Vulgaris

Lineage analysis of autoreactive B cells can reveal the origins of autoimmunity. In the autoimmune disease pemphigus vulgaris (PV), desmoglein 3 (DSG3) and DSG1 autoantibodies are predominantly of the IgG4 subclass and less frequently of IgG1 and IgA subclasses, prompting us to investigate whether a...

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Udgivet i:Cell Rep
Main Authors: Ellebrecht, Christoph T., Mukherjee, Eric M., Zheng, Qi, Choi, Eun Jung, Reddy, Shantan G., Mao, Xuming, Payne, Aimee S.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6156788/
https://ncbi.nlm.nih.gov/pubmed/30157430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.07.093
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