Tissue-specific effects of targeted mutation of Mir29b1 in rats

BACKGROUND: miR-29 is a master regulator of extracellular matrix genes, but conflicting data on its anti-fibrotic effect have been reported. miR-29 improves nitric oxide (NO) production in arterioles by targeting Lypla1. Mir29b1 targeted mutation exacerbates hypertension in a model derived from the...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Xue, Hong, Zhang, Guangyuan, Geurts, Aron M., Usa, Kristie, Jensen, David M., Liu, Yong, Widlansky, Michael E., Liang, Mingyu
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
Assuntos:
Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6156712/
https://ncbi.nlm.nih.gov/pubmed/30120082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.08.016
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