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Remote electrochemical modulation of pK(a) in a rotaxane by co-conformational allostery

Allosteric control, one of Nature’s most effective ways to regulate functions in biomolecular machinery, involves the transfer of information between distant sites. The mechanistic details of such a transfer are still an object of intensive investigation and debate, and the idea that intramolecular...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Ragazzon, Giulio, Schäfer, Christian, Franchi, Paola, Silvi, Serena, Colasson, Benoit, Lucarini, Marco, Credi, Alberto
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6156658/
https://ncbi.nlm.nih.gov/pubmed/29255033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1712783115
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