The evolution of multiple active site configurations in a designed enzyme

Developments in computational chemistry, bioinformatics, and laboratory evolution have facilitated the de novo design and catalytic optimization of enzymes. Besides creating useful catalysts, the generation and iterative improvement of designed enzymes can provide valuable insight into the interplay...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Hong, Nan-Sook, Petrović, Dušan, Lee, Richmond, Gryn’ova, Ganna, Purg, Miha, Saunders, Jake, Bauer, Paul, Carr, Paul D., Lin, Ching-Yeh, Mabbitt, Peter D., Zhang, William, Altamore, Timothy, Easton, Chris, Coote, Michelle L., Kamerlin, Shina C. L., Jackson, Colin J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6156567/
https://ncbi.nlm.nih.gov/pubmed/30254369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06305-y
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