Arginase 1 promotes retinal neurovascular protection from ischemia through suppression of macrophage inflammatory responses

The lack of effective therapies to limit neurovascular injury in ischemic retinopathy is a major clinical problem. This study aimed to examine the role of ureohydrolase enzyme, arginase 1 (A1), in retinal ischemia-reperfusion (IR) injury. A1 competes with nitric oxide synthase (NOS) for their common...

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Publicado en:Cell Death Dis
Main Authors: Fouda, Abdelrahman Y., Xu, Zhimin, Shosha, Esraa, Lemtalsi, Tahira, Chen, Jijun, Toque, Haroldo A., Tritz, Rebekah, Cui, Xuezhi, Stansfield, Brian K., Huo, Yuqing, Rodriguez, Paulo C., Smith, Sylvia B., Caldwell, R. William, Narayanan, S. Priya, Caldwell, Ruth B.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6156564/
https://ncbi.nlm.nih.gov/pubmed/30254218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-1051-6
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