The CBM-opathies—A Rapidly Expanding Spectrum of Human Inborn Errors of Immunity Caused by Mutations in the CARD11-BCL10-MALT1 Complex

The caspase recruitment domain family member 11 (CARD11 or CARMA1)—B cell CLL/lymphoma 10 (BCL10)—MALT1 paracaspase (MALT1) [CBM] signalosome complex serves as a molecular bridge between cell surface antigen receptor signaling and the activation of the NF-κB, JNK, and mTORC1 signaling axes. This pos...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Lu, Henry Y., Bauman, Bradly M., Arjunaraja, Swadhinya, Dorjbal, Batsukh, Milner, Joshua D., Snow, Andrew L., Turvey, Stuart E.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6156466/
https://ncbi.nlm.nih.gov/pubmed/30283440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02078
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