Neoflavonoids as Inhibitors of HIV-1 Replication by Targeting the Tat and NF-κB Pathways

Twenty-eight neoflavonoids have been prepared and evaluated in vitro against HIV-1. Antiviral activity was assessed on MT-2 cells infected with viral clones carrying the luciferase reporter gene. Inhibition of HIV transcription and Tat function were tested on cells stably transfected with the HIV-LT...

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Veröffentlicht in:Molecules
Hauptverfasser: Olmedo, Dionisio A., López-Pérez, José Luis, del Olmo, Esther, Bedoya, Luis M., Sancho, Rocío, Alcamí, José, Muñoz, Eduardo, San Feliciano, Arturo, Gupta, Mahabir P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6155902/
https://ncbi.nlm.nih.gov/pubmed/28218730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22020321
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