Improved glycemic control with minimal systemic metformin exposure: Effects of Metformin Delayed-Release (Metformin DR) targeting the lower bowel over 16 weeks in a randomized trial in subjects with type 2 diabetes

OBJECTIVE: Metformin use is restricted in patients with renal impairment due to potential excess systemic accumulation. This study evaluated the glycemic effects and safety of metformin delayed-release (Metformin DR), which targets metformin delivery to the ileum to leverage its gut-based mechanisms...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Henry, Robert R., Frias, Juan P., Walsh, Brandon, Skare, Sharon, Hemming, John, Burns, Colleen, Bicsak, Thomas A., Baron, Alain, Fineman, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6155522/
https://ncbi.nlm.nih.gov/pubmed/30252913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0203946
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