Phosphoglycerate dehydrogenase inhibition induces p-mTOR-independent autophagy and promotes multilineage differentiation in embryonal carcinoma stem-like cells

Cancer cells with a less differentiated stem-like phenotype are more resistant to therapeutic manipulations than their differentiated counterparts, and are considered as one of the main causes of cancer persistence and relapse. As such, induction of differentiation in cancer stem-like cells (CSLCs)...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Death Dis
Egile Nagusiak: Sharif, Tanveer, Martell, Emma, Dai, Cathleen, Ghassemi-Rad, Mohammad Saleh, Lee, Kristen, Singh, Sheila K., Weaver, Ian C. G., Gujar, Shashi
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6155240/
https://ncbi.nlm.nih.gov/pubmed/30250195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0997-8
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