Crystal structures of multicopper oxidase CueO G304K mutant: structural basis of the increased laccase activity

The multicopper oxidase CueO is involved in copper homeostasis and copper (Cu) tolerance in Escherichia coli. The laccase activity of CueO G304K mutant is higher than wild-type CueO. To explain this increase in activity, we solved the crystal structure of G304K mutant at 1.49 Å. Compared with wild-t...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Sci Rep
Päätekijät: Wang, Hanqian, Liu, Xiaoqing, Zhao, Jintong, Yue, Qingxia, Yan, Yuhua, Gao, Zengqiang, Dong, Yuhui, Zhang, Zhiyong, Fan, Yunliu, Tian, Jian, Wu, Ningfeng, Gong, Yong
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2018
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6155172/
https://ncbi.nlm.nih.gov/pubmed/30250139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-32446-7
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