The pathogenesis linked to coenzyme Q10 insufficiency in iPSC-derived neurons from patients with multiple-system atrophy

Multiple-system atrophy (MSA) is a neurodegenerative disease characterized by autonomic failure with various combinations of parkinsonism, cerebellar ataxia, and pyramidal dysfunction. We previously reported that functionally impaired variants of COQ2, which encodes an essential enzyme in the biosyn...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Nakamoto, Fumiko Kusunoki, Okamoto, Satoshi, Mitsui, Jun, Sone, Takefumi, Ishikawa, Mitsuru, Yamamoto, Yorihiro, Kanegae, Yumi, Nakatake, Yuhki, Imaizumi, Kent, Ishiura, Hiroyuki, Tsuji, Shoji, Okano, Hideyuki
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6155102/
https://ncbi.nlm.nih.gov/pubmed/30242188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-32573-1
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