Tick galactosyltransferases are involved in α-Gal synthesis and play a role during Anaplasma phagocytophilum infection and Ixodes scapularis tick vector development

The carbohydrate Galα1-3Galβ1-(3)4GlcNAc-R (α-Gal) is produced in all mammals except for humans, apes and old world monkeys that lost the ability to synthetize this carbohydrate. Therefore, humans can produce high antibody titers against α-Gal. Anti-α-Gal IgE antibodies have been associated with tic...

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Vydáno v:Sci Rep
Hlavní autoři: Cabezas-Cruz, Alejandro, Espinosa, Pedro J., Alberdi, Pilar, Šimo, Ladislav, Valdés, James J., Mateos-Hernández, Lourdes, Contreras, Marinela, Rayo, Margarita Villar, de la Fuente, José
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6154994/
https://ncbi.nlm.nih.gov/pubmed/30242261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-32664-z
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