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Novel Approaches To Kill Toxoplasma gondii by Exploiting the Uncontrolled Uptake of Unsaturated Fatty Acids and Vulnerability to Lipid Storage Inhibition of the Parasite

Toxoplasma gondii, an obligate intracellular parasite replicating in mammalian cells within a parasitophorous vacuole (PV), is an avid scavenger of lipids retrieved from the host cell. Following lipid uptake, this parasite stores excess lipids in lipid droplets (LD). Here, we examined the lipid stor...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Nolan, Sabrina J., Romano, Julia D., Kline, John T., Coppens, Isabelle
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6153790/
https://ncbi.nlm.nih.gov/pubmed/30061287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00347-18
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