Modeling Wnt signaling by CRISPR-Cas9 genome editing recapitulates neoplasia in human Barrett epithelial organoids

Primary organoid cultures generated from patient biopsies comprise a novel improved platform for disease modeling, being genetically stable and closely recapitulating in vivo scenarios. Barrett esophagus (BE) is the major risk factor for esophageal adenocarcinoma. There has been a dearth of long-ter...

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Detalhes bibliográficos
Publicado no:Cancer Lett
Main Authors: Liu, Xi, Cheng, Yulan, Abraham, John M., Wang, Zhixiong, Wang, Zhe, Ke, Xiquan, Yan, Rong, Shin, Eun Ji, Ngamruengphong, Saowanee, Khashab, Mouen, Zhang, Guanjun, McNamara, George, Ewald, Andrew J., Lin, DeChen, Liu, Zhengwen, Meltzer, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6152930/
https://ncbi.nlm.nih.gov/pubmed/30144514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2018.08.017
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