Loss of response to anti-tumor necrosis factor alpha therapy in Crohn’s disease is not associated with emergence of novel inflammatory pathways

BACKGROUND: While monoclonal antibodies against tumor necrosis factor-α (TNFα) are effective in treating Crohn’s disease (CD), approximately one-third of patients lose response. The mechanisms underlying this loss of response remain elusive. AIM: We sought to determine if novel biological pathways,...

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發表在:Dig Dis Sci
Main Authors: Luther, Jay, Gala, Manish, Patel, Suraj J., Dave, Maneesh, Borren, Nynke, Xavier, Ramnik J., Ananthakrishnan, Ashwin N.
格式: Artigo
語言:Inglês
出版: 2018
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6152907/
https://ncbi.nlm.nih.gov/pubmed/29372477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10620-018-4932-8
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