Novel isatin-derived molecules activate p53 via interference with Mdm2 to promote apoptosis

The p53 protein is a key tumor suppressor in mammals. In response to various forms of genotoxic stress p53 stimulates expression of genes whose products induce cell cycle arrest and/or apoptosis. An E3-ubiquitin ligase, Mdm2 (mouse-double-minute 2) and its human ortholog Hdm2, physically interact wi...

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Détails bibliographiques
Publié dans:Cell Cycle
Auteurs principaux: Fedorova, Olga, Daks, Alexandra, Petrova, Varvara, Petukhov, Alexey, Lezina, Larissa, Shuvalov, Oleg, Davidovich, Pavel, Kriger, Darya, Lomert, Ekaterina, Tentler, Dmitry, Kartsev, Victor, Uyanik, Burhan, Tribulovich, Vyacheslav, Demidov, Oleg, Melino, Gerry, Barlev, Nickolai A.
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2018
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6152504/
https://ncbi.nlm.nih.gov/pubmed/30109812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2018.1506664
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