Synthesis and biological evaluation of pyrrolidine-based T-type calcium channel inhibitors for the treatment of neuropathic pain

The treatment of neuropathic pain is one of the urgent unmet medical needs and T-type calcium channels are promising therapeutic targets for neuropathic pain. Several potent T-type channel inhibitors showed promising in vivo efficacy in neuropathic pain animal models and are being investigated in cl...

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Bibliografische gegevens
Gepubliceerd in:J Enzyme Inhib Med Chem
Hoofdauteurs: Yang, Hak Kyun, Son, Woo Seung, Lim, Keon Seung, Kim, Gun Hee, Lim, Eun Jeong, Gadhe, Changdev G., Lee, Jae Yeol, Jeong, Kyu-Sung, Lim, Sang Min, Pae, Ae Nim
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Taylor & Francis 2018
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Original Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6151954/
https://ncbi.nlm.nih.gov/pubmed/30231778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2018.1513926
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