Ionic Liquid-Catalyzed Green Protocol for Multi-Component Synthesis of Dihydropyrano[2,3-c]pyrazoles as Potential Anticancer Scaffolds

A series of 6-amino-4-substituted-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles 5a–j were synthesized via one-pot, four-component condensation reactions of aryl aldehydes 1a–j, propanedinitrile (2), hydrazine hydrate (3) and ethyl acetoacetate (4) under solvent-free conditions. We report...

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Veröffentlicht in:Molecules
Hauptverfasser: Nimbalkar, Urja D., Seijas, Julio A., Vazquez-Tato, Maria Pilar, Damale, Manoj G., Sangshetti, Jaiprakash N., Nikalje, Anna Pratima G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6151819/
https://ncbi.nlm.nih.gov/pubmed/28956863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22101628
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