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Identification of Optically Active Pyrimidine Derivatives as Selective 5-HT(2C) Modulators

A series of pyrimidine derivatives 4a–i were synthesized and evaluated for their binding affinities towards 5-HT(2C) receptors. With regard to designed molecules 4a–i, the influence of the size of alkyl ether and the absolute configuration of a stereogenic center on the 5-HT(2C) binding affinity and...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Molecules
Prif Awduron: Kim, Juhyeon, Jo, Hanbyeol, Lee, Hyunseung, Choo, Hyunah, Kim, Hak Joong, Pae, Ae Nim, Cho, Yong Seo, Min, Sun-Joon
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: MDPI 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6151589/
https://ncbi.nlm.nih.gov/pubmed/28846591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22091416
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