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Synthesis of novel perillyl–dihydropyrimidinone hybrids designed for antiproliferative activity
A series of fifteen novel dihydropyrimidinone hybrid compounds were synthesized in good yields via a multicomponent reaction combined with the Huisgen reaction. The antiproliferative activity was investigated against nine tumor cell lines, and four hybrid compounds (TGI < 10 μM) showed promising...
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Publicado no: | Medchemcomm |
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Main Authors: | , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Royal Society of Chemistry
2018
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6151448/ https://ncbi.nlm.nih.gov/pubmed/30288229 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00270c |
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