GATA6 regulates aortic valve remodeling and its haploinsufficiency leads to RL-type Bicuspid Aortic Valve

BACKGROUND: Bicuspid aortic valve (BAV), the most common congenital heart defect affecting 1–2% of the population, is a major risk factor for premature aortic valve disease and accounts for the majority of valve replacement. The genetic basis and the mechanisms of BAV etiology and pathogenesis remai...

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Bibliografiske detaljer
Udgivet i:Circulation
Main Authors: Gharibeh, Lara, Komati, Hiba, Bossé, Yohan, Boodhwani, Munir, Heydarpour, Mahyar, Fortier, Megan, Hassanzadeh, Romina, Ngu, Janet, Mathieu, Patrick, Body, Simon, Nemer, Mona
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6151169/
https://ncbi.nlm.nih.gov/pubmed/29567669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.117.029506
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