Induction of Telomere Dysfunction Prolongs Disease Control of Therapy-Resistant Melanoma

PURPOSE: Telomerase promoter mutations are highly prevalent in human tumors including melanoma. A subset of patients with metastatic melanoma often fail multiple therapies and there is an unmet and urgent need to prolong disease control for those patients. EXPERIMENTAL DESIGN: Numerous pre-clinical...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Zhang, Gao, Wu, Lawrence W., Mender, Ilgen, Barzily-Rokni, Michal, Hammond, Marc R., Ope, Omotayo, Cheng, Chaoran, Vasilopoulos, Themistoklis, Randell, Sergio, Sadek, Norah, Beroard, Aurelie, Xiao, Min, Tian, Tian, Tan, Jiufeng, Saeed, Umar, Sugarman, Eric, Krepler, Clemens, Brafford, Patricia, Sproesser, Katrin, Murugan, Sengottuvelan, Somasundaram, Rajasekharan, Garman, Bradley, Wubbenhorst, Bradley, Woo, Jonathan, Yin, Xiangfan, Liu, Qin, Frederick, Dennie T., Miao, Benchun, Xu, Wei, Karakousis, Giorgos C., Xu, Xiaowei, Schuchter, Lynn M., Gangadhar, Tara C., Kwong, Lawrence N., Amaravadi, Ravi K., Lu, Yiling, Boland, Genevieve M., Wei, Zhi, Nathanson, Katherine, Herbig, Utz, Mills, Gordon B., Flaherty, Keith T., Herlyn, Meenhard, Shay, Jerry W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6150856/
https://ncbi.nlm.nih.gov/pubmed/29563139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-2773
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