Design, Synthesis, and Biological Activity of Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine Derivatives as Anti-Inflammatory Agents

We designed and synthesized 26 prototype compounds and studied their anti-inflammatory activity and underlying molecular mechanisms. The inhibitory effects of the compounds on the production of nitric oxide (NO), cytokines, inflammatory-related proteins, and mRNAs in lipopolysaccharide (LPS)-stimula...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Zhang, Yuan, Luo, Lu, Han, Chao, Lv, Handeng, Chen, Di, Shen, Guoliang, Wu, Kaiqi, Pan, Suwei, Ye, Faqing
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6150211/
https://ncbi.nlm.nih.gov/pubmed/29137170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22111960
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