In Vivo and In Vitro Activities and ADME-Tox Profile of a Quinolizidine-Modified 4-Aminoquinoline: A Potent Anti-P. falciparum and Anti-P. vivax Blood-Stage Antimalarial

Natural products are a prolific source for the identification of new biologically active compounds. In the present work, we studied the in vitro and in vivo antimalarial efficacy and ADME-Tox profile of a molecular hybrid (AM1) between 4-aminoquinoline and a quinolizidine moiety derived from lupinin...

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Publicat a:Molecules
Autors principals: Basilico, Nicoletta, Parapini, Silvia, Sparatore, Anna, Romeo, Sergio, Misiano, Paola, Vivas, Livia, Yardley, Vanessa, Croft, Simon L., Habluetzel, Annette, Lucantoni, Leonardo, Renia, Laurent, Russell, Bruce, Suwanarusk, Rossarin, Nosten, Francois, Dondio, Giulio, Bigogno, Chiara, Jabes, Daniela, Taramelli, Donatella
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6149971/
https://ncbi.nlm.nih.gov/pubmed/29194347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22122102
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