In Vivo and In Vitro Activities and ADME-Tox Profile of a Quinolizidine-Modified 4-Aminoquinoline: A Potent Anti-P. falciparum and Anti-P. vivax Blood-Stage Antimalarial

Natural products are a prolific source for the identification of new biologically active compounds. In the present work, we studied the in vitro and in vivo antimalarial efficacy and ADME-Tox profile of a molecular hybrid (AM1) between 4-aminoquinoline and a quinolizidine moiety derived from lupinin...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Molecules
Main Authors: Basilico, Nicoletta, Parapini, Silvia, Sparatore, Anna, Romeo, Sergio, Misiano, Paola, Vivas, Livia, Yardley, Vanessa, Croft, Simon L., Habluetzel, Annette, Lucantoni, Leonardo, Renia, Laurent, Russell, Bruce, Suwanarusk, Rossarin, Nosten, Francois, Dondio, Giulio, Bigogno, Chiara, Jabes, Daniela, Taramelli, Donatella
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2017
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6149971/
https://ncbi.nlm.nih.gov/pubmed/29194347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22122102
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker