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Formal Synthesis of the ACE Inhibitor Benazepril·HCl via an Asymmetric Aza-Michael Reaction
A formal enantioselective synthesis of benazepril·HCl (4), an anti-hypertensive drug, is reported. Our synthesis employed an asymmetric aza-Michael addition of L-homophenylalanine ethyl ester (LHPE, 1) to 4-(2-nitrophenyl)-4-oxo-but-2-enoic acid methyl ester (6) as the key step to prepare (2S,3’S)-2...
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| Publicado en: | Molecules |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
MDPI
2006
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6148483/ https://ncbi.nlm.nih.gov/pubmed/17971736 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/11080641 |
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