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Pechmann Reaction Promoted by Boron Trifluoride Dihydrate

The Pechmann reaction of substituted phenols 1a-e with methyl acetoacetate (2) can be activated by boron trifluoride dihydrate (3) to give the corresponding 4-methylcoumarin derivatives 4a-e in excellent yield (98-99 %).

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Pubblicato in:Molecules
Autori principali: Stoyanov, Edmont V., Mezger, Jochen
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2005
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6147532/
https://ncbi.nlm.nih.gov/pubmed/18007344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/10070762
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