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One Step Regioselective Synthesis of 5-Aminoisoxazoles from Nitrile Oxides and α-Cyanoenamines

The 1,3-dipolar cycloaddition of nitrile oxides to 1-cyanoenamines gives 5-aminoisoxazoles regioselectively. Moderate to good yields could be obtained depending on the method used to generate the nitrile oxides. The intermediate isoxazolines could not be isolated.

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Saad, Amar, Vaultier, Michel, Derdour, Aïcha
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6147346/
https://ncbi.nlm.nih.gov/pubmed/18007452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/90700527
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