Association of Ipilimumab With Safety and Antitumor Activity in Women With Metastatic or Recurrent Human Papillomavirus–Related Cervical Carcinoma

IMPORTANCE: Based on evidence of human papillomavirus (HPV)–induced immune evasion, immunotherapy may be an attractive strategy in cervical cancer. Ipilimumab is a fully humanized monoclonal antibody that blocks cytotoxic T-lymphocyte antigen-4 (CTLA-4), which acts to downregulate the T-cell immune...

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Detalhes bibliográficos
Publicado no:JAMA Oncol
Main Authors: Lheureux, Stephanie, Butler, Marcus O., Clarke, Blaise, Cristea, Mihaela C., Martin, Lainie P., Tonkin, Katia, Fleming, Gini F., Tinker, Anna V., Hirte, Hal W., Tsoref, Daliah, Mackay, Helen, Dhani, Neesha C., Ghatage, Prafull, Weberpals, Johanne, Welch, Stephen, Pham, Nhu-An, Motta, Vinicius, Sotov, Valentin, Wang, Lisa, Karakasis, Katherine, Udagani, Smitha, Kamel-Reid, Suzanne, Streicher, Howard Z., Shaw, Patricia, Oza, Amit M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Medical Association 2017
Assuntos:
Brief Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6145732/
https://ncbi.nlm.nih.gov/pubmed/29145543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2017.3776
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