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Easy and efficient production of completely embryonic-stem-cell-derived mice using a micro-aggregation device

There is an increasing demand for genetically modified mice produced without crossing, for rapid phenotypic screening studies at the organismal level. For this purpose, generation of completely embryonic-stem-cell (ESC)-derived chimeric mice without crossing is now possible using a microinjection or...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Sumiyama, Kenta, Matsumoto, Naomi, Garçon-Yoshida, Junko, Ukai, Hideki, Ueda, Hiroki R., Tanaka, Yo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6145547/
https://ncbi.nlm.nih.gov/pubmed/30231034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0203056
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