Symmetrical (SDMA) and asymmetrical dimethylarginine (ADMA) in sepsis: high plasma levels as combined risk markers for sepsis survival

BACKGROUND: Nitric oxide (NO) regulates processes involved in sepsis progression, including vascular and immune function. NO is generated by nitric oxide synthases (NOS) from L-arginine. Cellular L-arginine uptake is inhibited by symmetric dimethylarginine (SDMA) and asymmetric dimethylarginine (ADM...

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Publicado en:Crit Care
Autores principales: Winkler, Martin Sebastian, Nierhaus, Axel, Rösler, Gilbert, Lezius, Susanne, Harlandt, Olaf, Schwedhelm, Edzard, Böger, Rainer H., Kluge, Stefan
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2018
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Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6145330/
https://ncbi.nlm.nih.gov/pubmed/30231905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13054-018-2090-1
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