Decoding non-random mutational signatures at Cas9 targeted sites

The mutation patterns at Cas9 targeted sites contain unique information regarding the nuclease activity and repair mechanisms in mammalian cells. However, analytical framework for extracting such information are lacking. Here, we present a novel computational platform called Rational InDel Meta-Anal...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Taheri-Ghahfarokhi, Amir, Taylor, Benjamin J M, Nitsch, Roberto, Lundin, Anders, Cavallo, Anna-Lina, Madeyski-Bengtson, Katja, Karlsson, Fredrik, Clausen, Maryam, Hicks, Ryan, Mayr, Lorenz M, Bohlooly-Y, Mohammad, Maresca, Marcello
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Molecular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6144780/
https://ncbi.nlm.nih.gov/pubmed/30032200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky653
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