Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature

Defects in cerebrospinal fluid (CSF) flow may contribute to idiopathic scoliosis. However, the mechanisms underlying detection of CSF flow in the central canal of the spinal cord are unknown. Here we demonstrate that CSF flows bidirectionally along the antero-posterior axis in the central canal of z...

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Publicat a:Nat Commun
Autors principals: Sternberg, Jenna R., Prendergast, Andrew E., Brosse, Lucie, Cantaut-Belarif, Yasmine, Thouvenin, Olivier, Orts-Del’Immagine, Adeline, Castillo, Laura, Djenoune, Lydia, Kurisu, Shusaku, McDearmid, Jonathan R., Bardet, Pierre-Luc, Boccara, Claude, Okamoto, Hitoshi, Delmas, Patrick, Wyart, Claire
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6143598/
https://ncbi.nlm.nih.gov/pubmed/30228263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06225-x
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