Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity

Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder characterized by debilitating heterotopic ossification (HO). The retinoic acid receptor gamma agonist, palovarotene, and antibody-mediated activin A blockade have entered human clinical trials, but how these therapeutic modalitie...

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Pubblicato in:eLife
Autori principali: Lees-Shepard, John B, Nicholas, Sarah-Anne E, Stoessel, Sean J, Devarakonda, Parvathi M, Schneider, Michael J, Yamamoto, Masakazu, Goldhamer, David J
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2018
Soggetti:
Human Biology and Medicine
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6143342/
https://ncbi.nlm.nih.gov/pubmed/30226468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.40814
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