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Synthesis of indolo[1,2-c]quinazolines from 2-alkynylaniline derivatives through Pd-catalyzed indole formation/cyclization with N,N-dimethylformamide dimethyl acetal

An efficient strategy for the synthesis of 6-unsubstituted indolo[1,2-c]quinazolines is described. The Pd-catalyzed reaction of o-(o-aminophenylethynyl) trifluoroacetanilides with Ar–B(OH)(2) afforded 2-(o-aminophenyl)-3-arylindoles, that were converted to 12-arylindolo[1,2-c]quinazolines by adding...

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Detalles Bibliográficos
Publicado en:Beilstein J Org Chem
Main Authors: Arcadi, Antonio, Cacchi, Sandro, Fabrizi, Giancarlo, Ghirga, Francesca, Goggiamani, Antonella, Iazzetti, Antonia, Marinelli, Fabio
Formato: Artigo
Idioma:Inglês
Publicado: Beilstein-Institut 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6142776/
https://ncbi.nlm.nih.gov/pubmed/30254707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.14.218
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