Inhibition of epithelial cell migration and Src/FAK signaling by SIRT3

Metastasis remains the leading cause of cancer mortality, and reactive oxygen species (ROS) signaling promotes the metastatic cascade. However, the molecular pathways that control ROS signaling relevant to metastasis are little studied. Here, we identify SIRT3, a mitochondrial deacetylase, as a regu...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Lee, Jaewon J., van de Ven, Robert A. H., Zaganjor, Elma, Ng, Mei Rosa, Barakat, Amey, Demmers, Joris J. P. G., Finley, Lydia W. S., Gonzalez Herrera, Karina N., Hung, Yin Pun, Harris, Isaac S., Jeong, Seung Min, Danuser, Gaudenz, McAllister, Sandra S., Haigis, Marcia C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6142214/
https://ncbi.nlm.nih.gov/pubmed/29915029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1800440115
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